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Article

RACK1 stabilises the activity of PP2A to regulate the transformed phenotype in mammary epithelial cells.

Cellular signalling - 1 Jul 2017

Kiely Maeve, Adams David R, Hayes Sheri L, O'Connor Rosemary, Baillie George S, Kiely Patrick A

Abstract excerpt

Conflicting reports implicate the scaffolding protein RACK1 in the progression of breast cancer. RACK1 has been identified as a key regulator downstream of growth factor and adhesion signalling and as a direct binding partner of PP2A. Our objective was to further characterise the interaction between PP2A and RACK1 and to advance our understanding of this complex in breast cancer cells. We examined how the PP2A...

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Source

Identifiers

PMID: 27600565
DOI: 10.1016/j.cellsig.2016.09.001

Genes

RACK1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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