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Article

Suppression of PP2A-B56α drives EMT in EGFR mutant non-small cell lung cancer.

Oncogene - 1 Jun 2026

Heil Brittany N, Baral Garima, Pfeffer Claire M, Bahler Mei B, Gulavani Sanika S, Smith Emily G, Gartenhaus Lauren E, Darling Anna K, Clifford Sydney J, Smith-Kinnaman Whitney, Hansen Kasi, Doud Emma H, Mall Gaganpreet K, Hata Aaron N, Anderson Nicole L, Olson Matthew R, Allen-Petersen Brittany L

Abstract excerpt

Lung cancer is the leading cause of cancer-related deaths in the United States, and ~50% of these patients present with metastatic disease at diagnosis. Epithelial-to-Mesenchymal Transition (EMT) is an important initiating step in the metastatic cascade that allows cells to acquire the migratory and invasive phenotypes necessary for dissemination. The transcriptional reprogramming that takes place during EMT has...

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Share to Carcinoma, Non-Small-Cell Lung
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Epithelial-Mesenchymal Transition

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Share to Gene Expression Regulation, Neoplastic

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Source

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Identifiers

PMID: 41965447
DOI: 10.1038/s41388-026-03772-2
PMCID: PMC13167467

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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