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Article

Retention of virulence following colistin adaptation in Klebsiella pneumoniae is strain-dependent rather than associated with specific mutations.

Journal of medical microbiology - 1 Jul 2017

Wand Matthew E, Bock Lucy J, Sutton J Mark

Abstract excerpt

This study aimed to understand the impact on virulence and fitness of mutations in specific genes found after adaptation of Klebsiella pneumoniae to colistin. Isolates with an increase in their inhibitory concentration (MIC) to colistin of 32- to >128-fold were shown to have mutations in mgrB, phoPQ and pmrAB, all known regulators of pathways affecting membrane lipid content. When these strains were used in...

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PMID: 28741998
DOI: 10.1099/jmm.0.000530

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HAMP

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