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Article

Retention of virulence following adaptation to colistin in Acinetobacter baumannii reflects the mechanism of resistance.

The Journal of antimicrobial chemotherapy - 1 Aug 2015

Wand Matthew E, Bock Lucy J, Bonney Laura C, Sutton J Mark

Abstract excerpt

OBJECTIVES: Colistin resistance in Acinetobacter baumannii has been associated with loss of virulence and a negative impact on isolate selection. In this study, exposure of clinical isolates to suboptimal concentrations of colistin was used to explore the capacity to develop resistance by diverse mechanisms, and whether acquired resistance always reduces fitness and virulence. METHODS: Twelve colistin-susceptible...

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Identifiers

PMID: 25904728
DOI: 10.1093/jac/dkv097

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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