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Article

Analytical and biological variation in repeated sweat chloride concentrations in clinical trials for CFTR modulator therapy.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society - 1 Jan 2018

LeGrys V A, Moon T C, Laux J, Rock M J, Accurso F

Abstract excerpt

BACKGROUND: Using sweat chloride as a biomarker for CFTR modifying drugs requires knowledge of analytical and biological variation. METHODS: 979 sweat chloride concentrations from 128 subjects enrolled in the placebo arm of 2 multicenter, investigational drug trials were analyzed to determine coefficients of variation (CV) as well as reference change value (RCV) and index of individuality (II). RESULTS: For these...

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Identifiers

PMID: 28739209
DOI: 10.1016/j.jcf.2017.07.008
PMCID: PMC8179972

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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