Article

Multimatrix Monitoring of CFTR Modulators Reflecting Systemic Exposure, Airway Targeting, and Sweat Compartment in People with Cystic Fibrosis

2025-06-13

Abstract excerpt

Cystic fibrosis (CF) is a severe genetic disorder caused by mutations in the CFTR gene, leading to impaired chloride transport and multi-organ epithelial dysfunction. The advent of CFTR modulators, particularly the triple therapy elexacaftor/tezacaftor/ivacaftor (ETI), has revolutionized CF treatment. However, inter-individual variability in therapeutic response remains a challenge, often linked to pharmacokinetic...

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Literature Corpus work: a9e54277-77d3-5b86-9d91-d2c19d144cfc
DOI: 10.22541/au.174983623.39912131/v1

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