Article
Variability of sweat chloride concentration in subjects with cystic fibrosis and G551D mutations.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society - 1 Jan 2017
Vermeulen F, Le Camus C, Davies J C, Bilton D, Milenković D, De Boeck K
Abstract excerpt
INTRODUCTION: Sweat chloride concentration, a biomarker of CFTR function, is an appropriate outcome parameter in clinical trials aimed at correcting the basic CF defect. Although there is consensus on a cut-off value to diagnose CF, we have only limited information on the within subject variability of sweat chloride over time. Such information would be useful for sample size calculations in clinical trials....
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