Real-world data confirm elexacftor/tezacaftor/ivacaftor modulators halves sweat chloride concentration in eligible people with cystic fibrosis.

doi:10.1111/apm.13453

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Real-world data confirm elexacftor/tezacaftor/ivacaftor modulators halves sweat chloride concentration in eligible people with cystic fibrosis.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica - 1 Oct 2024

Bryrup Thomas, Faurholt-Jepsen Daniel, Pressler Tacjana, Henriksen Esben Herborg, Leo-Hansen Christian, Nielsen Bibi Uhre, Højte Christine, Mathiesen Inger Hee Mabuza, Katzenstein Terese L, Jeppesen Majbritt, Jensen-Fangel Søren, Olesen Hanne Vebert, Skov Marianne, Qvist Tavs, Olsen Mette Frahm

Abstract excerpt

Sweat chloride concentration, a diagnostic feature in cystic fibrosis (CF), reflects CF transmembrane conductance regulator (CFTR) activity. CFTR modulator therapies, especially elexacaftor/tezacaftor/ivacaftor (ETI), has improved CF outcomes. We report nationwide, real-world data on sweat chloride concentration in people with CF (pwCF) with and without modulator therapies. All Danish pwCF with a minimum of one...

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PMID: 39092470
DOI: 10.1111/apm.13453

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