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Article

Sweat chloride as a biomarker of CFTR activity: proof of concept and ivacaftor clinical trial data.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society - 1 Mar 2014

Accurso Frank J, Van Goor Fredrick, Zha Jiuhong, Stone Anne J, Dong Qunming, Ordonez Claudia L, Rowe Steven M, Clancy John Paul, Konstan Michael W, Hoch Heather E, Heltshe Sonya L, Ramsey Bonnie W, Campbell Preston W, Ashlock Melissa A

Abstract excerpt

BACKGROUND: We examined data from a Phase 2 trial {NCT00457821} of ivacaftor, a CFTR potentiator, in cystic fibrosis (CF) patients with aG551D mutation to evaluate standardized approaches to sweat chloride measurement and to explore the use of sweat chloride and nasal potential difference (NPD) t...

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Identifiers

PMID: 24660233
DOI: 10.1016/j.jcf.2013.09.007
PMCID: PMC4102431

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24660233-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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