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Sources of Variation in Sweat Chloride Measurements in Cystic Fibrosis

3 Jun 2016

Abstract excerpt

Abstract Rationale Expanding the use of cystic fibrosis transmembrane conductance regulator (CFTR) potentiators and correctors for the treatment of cystic fibrosis (CF) requires precise and accurate biomarkers. Sweat chloride concentration provides an in vivo assessment of CFTR function, but it is unknown the degree to which CFTR mutations account for sweat chloride variation. Objectives To estimate potential...

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PMID: 27258095
DOI: 10.1164/rccm.201603-0459oc

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