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Article

In vivo readout of CFTR function: ratiometric measurement of CFTR-dependent secretion by individual, identifiable human sweat glands.

PloS one - 1 Jan 2013

Wine Jeffrey J, Char Jessica E, Chen Jonathan, Cho Hyung-Ju, Dunn Colleen, Frisbee Eric, Joo Nam Soo, Milla Carlos, Modlin Sara E, Park Il-Ho, Thomas Ewart A C, Tran Kim V, Verma Rohan, Wolfe Marlene H

Abstract excerpt

To assess CFTR function in vivo, we developed a bioassay that monitors and compares CFTR-dependent and CFTR-independent sweat secretion in parallel for multiple (~50) individual, identified glands in each subject. Sweating was stimulated by intradermally injected agonists and quantified by optica...

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Source

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Identifiers

PMID: 24204751
DOI: 10.1371/journal.pone.0077114
PMCID: PMC3811985

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24204751-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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