Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Calibrating sweat chloride levels to CFTR activity via ETI effects on CF subjects with one or two F508DEL mutations.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society - 1 Nov 2024

Wine Jeffrey J

Abstract excerpt

BACKGROUND: It is difficult to determine CFTR activity following highly effective CFTR modulator therapies (HEMT). The sweat gland provides two biomarkers of CFTR activity: a linear readout via the β-sweat rate and a logarithmic readout via sweat chloride concentration (SCC). In prior work, different logarithmic functions were generated to calibrate SCC with the percent of healthy control CFTR activity (HCCFTR)....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aminophenols
Share to Benzodioxoles
Share to Calibration

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chloride Channel Agonists

Share to Chlorides

Share to Pyrrolidines

Share to Quinolines

Source

Identifiers

PMID: 39406575
DOI: 10.1016/j.jcf.2024.09.004

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Calibrating sweat chloride levels to CFTR activity via ETI effects on CF subjects with one or two F508DEL mutations.PMID 39406575Read ↗

How the sweat gland reveals levels of CFTR activity.Semantic proximity Read ↗

Genotype-dependent biochemical response to elexacaftor/tezacaftor/ivacaftor in children with cystic fibrosis: A 24-month real-world study.Semantic proximity Read ↗

Real-world data confirm elexacftor/tezacaftor/ivacaftor modulators halves sweat chloride concentration in eligible people with cystic fibrosis.Semantic proximity Read ↗

Correlating Cystic Fibrosis Transmembrane Conductance Regulator Function with Clinical Features to Inform Precision Treatment of Cystic FibrosisSemantic proximity Read ↗

Characterizing CFTR modulated sweat chloride response across the cf population: Initial results from the CHEC-SC study.Semantic proximity Read ↗

In vivo readout of CFTR function: ratiometric measurement of CFTR-dependent secretion by individual, identifiable human sweat glands.Semantic proximity Read ↗

Heterogeneity of CFTR modulator-induced sweat chloride concentrations in people with cystic fibrosis.Semantic proximity Read ↗

Clinical and primary cell evidence reveals complex CFTR function–phenotype relationshipsSemantic proximity Read ↗

Impact of CFTR modulator concentrations on clinical response in cystic fibrosis.Semantic proximity Read ↗

Assessing accuracy of testing and diagnosis in cystic fibrosis.Semantic proximity Read ↗

Personalized CFTR Modulator Therapy for G85E and N1303K Homozygous Patients with Cystic Fibrosis.Semantic proximity Read ↗

Multimatrix Monitoring of CFTR Modulators Reflecting Systemic Exposure, Airway Targeting, and Sweat Compartment in People with Cystic FibrosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.