Article
GATA-1 modulates the chromatin structure and activity of the chicken alpha-globin 3' enhancer.
Molecular and cellular biology - 1 Jan 2008
Escamilla-Del-Arenal Martín, Recillas-Targa Félix
Abstract excerpt
Long-distance regulatory elements and local chromatin structure are critical for proper regulation of gene expression. Here we characterize the chromatin conformation of the chicken alpha-globin silencer-enhancer elements located 3' of the domain. We found a characteristic and erythrocyte-specific structure between the previously defined silencer and the enhancer, defined by two nuclease hypersensitive sites,...
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