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Article

The role of RGS protein in agonist-dependent relaxation of GIRK currents in Xenopus oocytes.

Biochemical and biophysical research communications - 25 Nov 2011

Sahlholm Kristoffer

Abstract excerpt

G protein coupled inward rectifier K(+) channels (GIRK) are activated by the G(βγ) subunits of G proteins upon activation of G protein coupled receptors (GPCRs). Receptor-stimulated GIRK currents are known to possess a curious property, termed "agonist-dependent relaxation," denoting a slow current increase upon stepping the membrane voltage from positive to negative potentials. Regulators of G protein signaling...

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Identifiers

PMID: 22068057
DOI: 10.1016/j.bbrc.2011.10.106

Genes

RGS4

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