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Article

A role for Leu247 residue within transmembrane domain 2 in ginsenoside-mediated alpha7 nicotinic acetylcholine receptor regulation.

Molecules and cells - 31 May 2009

Lee Byung-Hwan, Choi Sun-Hye, Pyo Mi Kyung, Shin Tae-Joon, Hwang Sung-Hee, Kim Bo-Ra, Lee Sang-Mok, Lee Jun-Ho, Lee Joon-Hee, Lee Hui Sun, Choe Han, Han Kyou-Hoon, Kim Hyoung-Chun, Rhim Hyewhon, Yong Joon-Hwan, Nah Seung-Yeol

Abstract excerpt

Nicotinic acetylcholine receptors (nAChRs) play important roles in nervous system functions and are involved in a variety of diseases. We previously demonstrated that ginsenosides, the active ingredients of Panax ginseng, inhibit subsets of nAChR channel currents, but not alpha7, expressed in Xenopus laevis oocytes. Mutation of the highly conserved Leu247 to Thr247 in the transmembrane domain 2 (TM2) channel pore...

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PMID: 19466608
DOI: 10.1007/s10059-009-0073-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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