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TCR repertoire intratumor heterogeneity of CD4+ and CD8+ T cells in centers and margins of localized lung adenocarcinomas

29 Aug 2018

Abstract excerpt

Intratumor heterogeneity (ITH) of T cell receptor (TCR) repertoire in different T‐cell subsets and locations in lung adenocarcinomas was unclear. Here, we investigated percentages and TCR repertoire of freshly isolated CD4+ and CD8+ tumor infiltrating lymphocytes (TILs) in tumor centers and margins by flow cytometry on 80 tumor samples from 20 patients and high‐throughput TCR sequencing on 27 and 25 samples of...

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PMID: 30151844
DOI: 10.1002/ijc.31760

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