Article
Association between the Prevalence of Somatic Mutations in PIK3CA Gene in Tumors and Clinical and Morphological Characteristics of Breast Cancer Patients.
Bulletin of experimental biology and medicine - 1 Jun 2017
Filipenko M L, Os'kina N A, Oskorbin I A, Mishukova O V, Ovchinnikova L K, Gershtein E S, Kushlinskii N E
Abstract excerpt
The presence of activating somatic mutations in codons 542 and 545 of exon 9 (p.E542K c.1624G>A and p.E545K c.1633G>A) and in codon 1047 of exon 20 (p.H1047R c.3140A>G and p.H1047L c.3140A>T) of PIK3CA gene encoding catalytic p110α-subunit of phosphatidylinositol-3-kinase was studied in tumors of 473 breast cancer patients by multiplex allele-specific real-time PCR. Fifty-eight (12.3%) different mutations were...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.