Article
The MIF promoter SNP rs755622 is associated with immune activation in glioblastoma.
JCI insight - 10 Jul 2023
Alban Tyler J, Grabowski Matthew M, Otvos Balint, Bayik Defne, Wang Wesley, Zalavadia Ajay, Makarov Vlad, Troike Katie, McGraw Mary, Rabljenovic Anja, Lauko Adam, Neumann Chase, Roversi Gustavo, Waite Kristin A, Cioffi Gino, Patil Nirav, Tran Thuy T, McCortney Kathleen, Steffens Alicia, Diaz C Marcela, Brown J Mark, Egan Kathleen M, Horbinski Craig M, Barnholtz-Sloan Jill S, Rajappa Prajwal, Vogelbaum Michael A, Bucala Richard, Chan Timothy A, Ahluwalia Manmeet S, Lathia Justin D
Abstract excerpt
Intratumoral heterogeneity is a defining hallmark of glioblastoma, driving drug resistance and ultimately recurrence. Many somatic drivers of microenvironmental change have been shown to affect this heterogeneity and, ultimately, the treatment response. However, little is known about how germline mutations affect the tumoral microenvironment. Here, we find that the single-nucleotide polymorphism (SNP) rs755622 in...
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