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Article

Dissecting the clinical heterogeneity of early-onset Alzheimer's disease.

Molecular psychiatry - 1 Jun 2022

Sirkis Daniel W, Bonham Luke W, Johnson Taylor P, La Joie Renaud, Yokoyama Jennifer S

Abstract excerpt

Early-onset Alzheimer's disease (EOAD) is a rare but particularly devastating form of AD. Though notable for its high degree of clinical heterogeneity, EOAD is defined by the same neuropathological hallmarks underlying the more common, late-onset form of AD. In this review, we describe the various clinical syndromes associated with EOAD, including the typical amnestic phenotype as well as atypical variants...

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Identifiers

PMID: 35393555
DOI: 10.1038/s41380-022-01531-9
PMCID: PMC9156414

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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