Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MUC1-Mediated Metabolic Alterations Regulate Response to Radiotherapy in Pancreatic Cancer

18 Jul 2017

Abstract excerpt

Abstract Purpose: MUC1, an oncogene overexpressed in multiple solid tumors, including pancreatic cancer, reduces overall survival and imparts resistance to radiation and chemotherapies. We previously identified that MUC1 facilitates growth-promoting metabolic alterations in pancreatic cancer cells. The present study investigates the role of MUC1-mediated metabolism in radiation resistance of pancreatic cancer by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to Cancer, Hypoxia, and Metabolism
Share to Pancreatic and Hepatic Oncology Research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28720669
DOI: 10.1158/1078-0432.ccr-17-1151

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MUC1-Mediated Metabolic Alterations Regulate Response to Radiotherapy in Pancreatic CancerPMID 28720669Read ↗

The reciprocal loop of MALAT1 and HIF-1α facilitates gemcitabine resistance in pancreatic cancer by enhancing glycolysisSemantic proximity Read ↗

M2 isoform of pyruvate kinase rewires glucose metabolism during radiation therapy to promote an antioxidant response and glioblastoma radioresistanceSemantic proximity Read ↗

Deletion of ENO1 sensitizes pancreatic cancer cells to gemcitabine via MYC/RRM1-mediated glycolysisSemantic proximity Read ↗

FOXM1 Promotes the Warburg Effect and Pancreatic Cancer Progression via Transactivation of LDHA ExpressionSemantic proximity Read ↗

MUC1-C oncoprotein regulates glycolysis and pyruvate kinase M2 activity in cancer cells.Semantic proximity Read ↗

MiR-135 suppresses glycolysis and promotes pancreatic cancer cell adaptation to metabolic stress by targeting phosphofructokinase-1Semantic proximity Read ↗

Uridine-derived ribose fuels glucose-restricted pancreatic cancerSemantic proximity Read ↗

Glutamine transporters regulate prostate cancer radiosensitivity through NUPR1-mediated stress responseSemantic proximity Read ↗

Low-dose arsenic-mediated metabolic shift is associated with activation of Polo-like kinase 1 (Plk1).Semantic proximity Read ↗

RAD51 is a potential marker for prognosis and regulates cell proliferation in pancreatic cancerSemantic proximity Read ↗

Reprogramming of tumor metabolism by targeting mitochondria improves tumor response to irradiation.Semantic proximity Read ↗

HPV, tumour metabolism and novel target identification in head and neck squamous cell carcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.