Article
Reprogramming of tumor metabolism by targeting mitochondria improves tumor response to irradiation.
Acta oncologica (Stockholm, Sweden) - 1 Feb 2015
Bol Vanesa, Bol Anne, Bouzin Caroline, Labar Daniel, Lee John A, Janssens Guillaume, Porporato Paolo E, Sonveaux Pierre, Feron Olivier, Grégoire Vincent
Abstract excerpt
BACKGROUND: The Warburg phenotype identified decades ago describes tumor cells with increased glycolysis and decreased mitochondrial respiration even in the presence of oxygen. This particular metabolism also termed 'aerobic glycolysis' reflects an adaptation of tumor cells to proliferation in a heterogeneous tumor microenvironment. Although metabolic alterations in cancer cells are common features, their impact...
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