Article
Low-dose arsenic-mediated metabolic shift is associated with activation of Polo-like kinase 1 (Plk1).
Cell cycle (Georgetown, Tex.) - 1 Jan 2015
Li Zhiguo, Lu Ying, Ahmad Nihal, Strebhardt Klaus, Liu Xiaoqi
Abstract excerpt
Arsenic is a well-established human carcinogen associated with cancers of the skin, liver, lung, kidney, and bladder. Although numerous carcinogenic pathways have been proposed, the molecular mechanisms underlying arsenic-associated cancer etiology are still elusive. The cellular responses to arsenic exposure are dose dependent. It was recently shown that low-dose arsenic leads to a metabolic shift from...
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