Article

The reciprocal loop of MALAT1 and HIF-1α facilitates gemcitabine resistance in pancreatic cancer by enhancing glycolysis

2021-04-12

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Profound chemoresistance is a prominent and intractable problem in pancreatic cancer. Gemcitabine, a first-line chemotherapeutic drug for pancreatic cancer, has provided only minimal benefits for patients; however, the underlying mechanisms remain to be investigated. Enhanced aerobic glycolysis has been suggested to be correlated with the phenotype of drug resis...

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Literature Corpus work: c6e9b908-690c-57f4-94db-15265171a732
DOI: 10.21203/rs.3.rs-135235/v2

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