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FOXM1 Promotes the Warburg Effect and Pancreatic Cancer Progression via Transactivation of LDHA Expression

14 Mar 2014

Abstract excerpt

PURPOSE: The transcription factor Forkhead box protein M1 (FOXM1) plays critical roles in cancer development and progression. However, the regulatory role and underlying mechanisms of FOXM1 in cancer metabolism are unknown. In this study, we characterized the regulation of aerobic glycolysis by FOXM1 and its impact on pancreatic cancer metabolism. EXPERIMENTAL DESIGN: The effect of altered expression of FOXM1 on...

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PMID: 24634381
DOI: 10.1158/1078-0432.ccr-13-2407

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