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Uridine-derived ribose fuels glucose-restricted pancreatic cancer

17 May 2023

Abstract excerpt

. Although altered metabolism drives tumour progression, the spectrum of metabolites used as nutrients by PDA remains largely unknown. Here we identified uridine as a fuel for PDA in glucose-deprived conditions by assessing how more than 175 metabolites impacted metabolic activity in 21 pancreatic cell lines under nutrient restriction. Uridine utilization strongly correlated with the expression of uridine...

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Share to Epigenetics and DNA Methylation
Share to Pancreatic and Hepatic Oncology Research
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PMID: 37198494
DOI: 10.1038/s41586-023-06073-w

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