Article
Genetic determinants of susceptibility to silver nanoparticle-induced acute lung inflammation in mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Oct 2017
Scoville David K, Botta Dianne, Galdanes Karen, Schmuck Stefanie C, White Collin C, Stapleton Patricia L, Bammler Theo K, MacDonald James W, Altemeier William A, Hernandez Michelle, Kleeberger Steven R, Chen Lung-Chi, Gordon Terry, Kavanagh Terrance J
Abstract excerpt
Silver nanoparticles (AgNPs) are employed in a variety of consumer products; however, in vivo rodent studies indicate that AgNPs can cause lung inflammation and toxicity in a strain- and particle type-dependent manner, but mechanisms of susceptibility remain unclear. The aim of this study was to assess the variation in AgNP-induced lung inflammation and toxicity across multiple inbred mouse strains and to use...
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