Article
Genetic variance is associated with susceptibility for cigarette smoke-induced DAMP release in mice.
American journal of physiology. Lung cellular and molecular physiology - 1 Sept 2017
Pouwels Simon D, Faiz Alen, den Boef Lisette E, Gras Reneé, van den Berge Maarten, Boezen H Marike, Korstanje Ron, Ten Hacken Nick H T, van Oosterhout Antoon J M, Heijink Irene H, Nawijn Martijn C
Abstract excerpt
Chronic obstructive pulmonary disease (COPD) is characterized by unresolved neutrophilic airway inflammation and is caused by chronic exposure to toxic gases, such as cigarette smoke (CS), in genetically susceptible individuals. Recent data indicate a role for damage-associated molecular patterns (DAMPs) in COPD. Here, we investigated the genetics of CS-induced DAMP release in 28 inbred mouse strains....
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