Article
Rapid identification of a Mycobacterium tuberculosis full genetic drug resistance profile through whole genome sequencing directly from sputum.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases - 1 Sept 2017
Nimmo Camus, Doyle Ronan, Burgess Carrie, Williams Rachel, Gorton Rebecca, McHugh Timothy D, Brown Mike, Morris-Jones Stephen, Booth Helen, Breuer Judith
Abstract excerpt
INTRODUCTION: Resistance to second-line tuberculosis drugs is common, but slow to diagnose with phenotypic drug sensitivity testing. Rapid molecular tests speed up diagnosis, but can only detect limited mutations. Whole genome sequencing (WGS) of culture isolates can generate a complete genetic drug resistance profile, but is delayed by the initial culture step. In the case presented here, successful WGS directly...
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