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Article

Genotypic drug resistance using whole-genome sequencing of Mycobacterium tuberculosis clinical isolates from North-western Tanzania.

Tuberculosis (Edinburgh, Scotland) - 1 Mar 2018

Kidenya Benson R, Mshana Stephen E, Fitzgerald Daniel W, Ocheretina Oksana

Abstract excerpt

BACKGROUND: Drug resistant Tuberculosis (TB) is considered a global public health threat. Whole-genome sequencing (WGS) is a new technology for tuberculosis (TB) diagnostics and is capable of providing rapid drug resistance profiles and genotypes for epidemiologic surveillance. Therefore, we used WGS to determine genotypic drug resistance profiles and genetic diversity of drug resistant Mycobacterium tuberculosis...

Topics

Adult
Antitubercular Agents
Bacteriological Techniques
Cross-Sectional Studies
DNA Mutational Analysis
DNA, Bacterial
Drug Resistance, Multiple, Bacterial
Female
Genotype
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Microbial Sensitivity Tests

Middle Aged

Molecular Epidemiology

Mutation

Mycobacterium tuberculosis

Phenotype

Tanzania

Source

Open in PubMed Open full text

Identifiers

PMID: 29559127
DOI: 10.1016/j.tube.2018.02.004
PMCID: PMC5912878

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-29559127-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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