Article
Whole genome sequencing of Mycobacterium tuberculosis isolates and clinical outcomes of patients treated for multidrug-resistant tuberculosis in Tanzania.
BMC genomics - 21 Feb 2020
Katale Bugwesa Z, Mbelele Peter M, Lema Nsiande A, Campino Susana, Mshana Stephen E, Rweyemamu Mark M, Phelan Jody E, Keyyu Julius D, Majigo Mtebe, Mbugi Erasto V, Dockrell Hazel M, Clark Taane G, Matee Mecky I, Mpagama Stellah
Abstract excerpt
BACKGROUND: Tuberculosis (TB), particularly multi- and or extensive drug resistant TB, is still a global medical emergency. Whole genome sequencing (WGS) is a current alternative to the WHO-approved probe-based methods for TB diagnosis and detection of drug resistance, genetic diversity and transmission dynamics of Mycobacterium tuberculosis complex (MTBC). This study compared WGS and clinical data in...
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