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Targeted next generation sequencing directly from sputum for comprehensive genetic information on drug resistant Mycobacterium tuberculosis.

Tuberculosis (Edinburgh, Scotland) - 1 Mar 2021

Kambli Priti, Ajbani Kanchan, Kazi Mubin, Sadani Meeta, Naik Swapna, Shetty Anjali, Tornheim Jeffrey A, Singh Harpreet, Rodrigues Camilla

Abstract excerpt

BACKGROUND: Timely drug resistance detection is essential to global tuberculosis management. Unfortunately, rapid molecular tests assess resistance to only a few drugs, with culture required for comprehensive susceptibility test results. METHODS: We evaluated targeted next generation sequencing (tNGS) for tuberculosis on 40 uncultured sputum samples. Resistance profiles from tNGS were compared with profiles from...

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PMID: 33450448
DOI: 10.1016/j.tube.2021.102051

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