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Whole genome enrichment approach for rapid detection of Mycobacterium tuberculosis and drug resistance-associated mutations from direct sputum sequencing.

Tuberculosis (Edinburgh, Scotland) - 1 Mar 2020

Soundararajan Lakshmi, Kambli Priti, Priyadarshini Sushri, Let Biswajit, Murugan Sakthivel, Iravatham Chitra, Tornheim Jeffrey A, Rodrigues Camilla, Gupta Ravi, Ramprasad V L

Abstract excerpt

Tuberculosis is the leading cause of death among infectious diseases worldwide. Detection of Mycobacterium tuberculosis (Mtb), using routine culture-based methods is time consuming resulting in delayed diagnosis and poor treatment outcomes. Currently available molecular tests provide faster diagnosis but are able to screen only limited hot-spot mutations. Whole genome sequencing from direct sputum offers a...

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PMID: 32279871
DOI: 10.1016/j.tube.2020.101915

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