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Article

LRRK2 and RIPK2 variants in the NOD 2-mediated signaling pathway are associated with susceptibility to Mycobacterium leprae in Indian populations.

PloS one - 1 Jan 2013

Marcinek Patrick, Jha Aditya Nath, Shinde Vidyagouri, Sundaramoorthy Arun, Rajkumar Raja, Suryadevara Naveen Chandra, Neela Sanjeev Kumar, van Tong Hoang, Balachander Vellingiri, Valluri Vijaya Lakshmi, Thangaraj Kumarasamy, Velavan Thirumalaisamy P

Abstract excerpt

In recent years, genome wide association studies have discovered a large number of gene loci that play a functional role in innate and adaptive immune pathways associated with leprosy susceptibility. The immunological control of intracellular bacteria M. leprae is modulated by NOD2-mediated signaling of Th1 responses. In this study, we investigated 211 clinically classified leprosy patients and 230 ethnically...

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Source

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Identifiers

PMID: 24015287
DOI: 10.1371/journal.pone.0073103
PMCID: PMC3756038

Genes

NOD2
RIPK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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