Article
A small molecule activator of SIRT3 promotes deacetylation and activation of manganese superoxide dismutase.
Free radical biology & medicine - 1 Nov 2017
Lu Jiaqi, Zhang Hua, Chen Xian, Zou Yong, Li Jiasong, Wang Li, Wu Minhao, Zang Jianye, Yu Yang, Zhuang Wei, Xia Qing, Wang Jiangyun
Abstract excerpt
The modulation of protein acetylation network is a promising strategy for life span extension and disease treatment (Sabari et al., 2016; Giblin et al., 2014) [1,2]. A variety of small molecules have been developed to target deacetylases, but extremely few of these molecules are capable of activating the mitochondrial NAD-dependent deacetylase sirtuin-3 (SIRT3) (Gertz and Steegborn, 2016; Scholz et al., 2015)...
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