Article
Acylation of Superoxide Dismutase 1 (SOD1) at K122 Governs SOD1-Mediated Inhibition of Mitochondrial Respiration.
Molecular and cellular biology - 15 Oct 2017
Banks Courtney J, Rodriguez Nathan W, Gashler Kyle R, Pandya Rushika R, Mortenson Jeffrey B, Whited Matthew D, Soderblom Erik J, Thompson J Will, Moseley M Arthur, Reddi Amit R, Tessem Jeffery S, Torres Matthew P, Bikman Benjamin T, Andersen Joshua L
Abstract excerpt
In this study, we employed proteomics to identify mechanisms of posttranslational regulation on cell survival signaling proteins. We focused on Cu-Zn superoxide dismutase (SOD1), which protects cells from oxidative stress. We found that acylation of K122 on SOD1, while not impacting SOD1 catalytic activity, suppressed the ability of SOD1 to inhibit mitochondrial metabolism at respiratory complex I. We found that...
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