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Article

Molecular basis for hierarchical histone de-β-hydroxybutyrylation by SIRT3

9 Jul 2019

Abstract excerpt

Abstract Chemical modifications on histones constitute a key mechanism for gene regulation in chromatin context. Recently, histone lysine β-hydroxybutyrylation (Kbhb) was identified as a new form of histone acylation that connects starvation-responsive metabolism to epigenetic regulation. Sirtuins are a family of NAD + -dependent deacetylases. Through systematic profiling studies, we show that human SIRT3...

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PMID: 31636949
DOI: 10.1038/s41421-019-0103-0

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