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Article

Studies on the regulatory mechanism of isocitrate dehydrogenase 2 using acetylation mimics.

Scientific reports - 29 Aug 2017

Xu Yuqun, Liu Lingwen, Nakamura Akira, Someya Shinichi, Miyakawa Takuya, Tanokura Masaru

Abstract excerpt

Mitochondrial isocitrate dehydrogenase 2 (IDH2) converts NADP+ to NADPH and promotes regeneration of reduced glutathione (GSH) by supplying NADPH to glutathione reductase or thioredoxin reductase. We have previously shown that under calorie restriction, mitochondrial deacetylase Sirt3 deacetylates and activates IDH2, thereby regulating the mitochondrial glutathione antioxidant defense system in mice. To...

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Topics

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Share to Acetylation
Share to Enzyme Activation
Share to Isocitrate Dehydrogenase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Subunits

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Source

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Identifiers

PMID: 28852116
DOI: 10.1038/s41598-017-10337-7
PMCID: PMC5575304

Genes

IDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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