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Article

Sirtuin 3 silencing improves oxaliplatin efficacy through acetylation of MnSOD in colon cancer

11 Jan 2018

Abstract excerpt

Sirtuin 3 (SIRT3) is the major mitochondria deacetylase and regulates ROS levels by targeting several key proteins, such as those involved in mitochondrial function and antioxidant defenses. This way, SIRT3 balances ROS production and scavenging and promotes cell survival. The aim of this study was to analyze the effect of SIRT3 silencing on the antioxidant response in SW620 colon cancer cell line, and whether...

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Share to Antioxidant Activity and Oxidative Stress
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PMID: 29323702
DOI: 10.1002/jcp.26443

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