Article
Targeting of dopamine transporter to filopodia requires an outward-facing conformation of the transporter.
Scientific reports - 14 Jul 2017
Ma Shiqi, Cheng Mary H, Guthrie Daryl A, Newman Amy H, Bahar Ivet, Sorkin Alexander
Abstract excerpt
Dopamine transporter (DAT) has been shown to accumulate in filopodia in neurons and non-neuronal cells. To examine the mechanisms of DAT filopodial targeting, we used quantitative live-cell fluorescence microscopy, and compared the effects of the DAT inhibitor cocaine and its fluorescent analog JHC1-64 on the plasma membrane distribution of wild-type DAT and two non-functional DAT mutants, R60A and W63A, that do...
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