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Article

Attention deficit/hyperactivity disorder-derived coding variation in the dopamine transporter disrupts microdomain targeting and trafficking regulation.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 18 Apr 2012

Sakrikar Dhananjay, Mazei-Robison Michelle S, Mergy Marc A, Richtand Nathan W, Han Qiao, Hamilton Peter J, Bowton Erica, Galli Aurelio, Veenstra-Vanderweele Jeremy, Gill Michael, Blakely Randy D

Abstract excerpt

Attention deficit/hyperactivity disorder (ADHD) is the most commonly diagnosed disorder of school-age children. Although genetic and brain-imaging studies suggest a contribution of altered dopamine (DA) signaling in ADHD, evidence of signaling perturbations contributing to risk is largely circumstantial. The presynaptic, cocaine- and amphetamine (AMPH)-sensitive DA transporter (DAT) constrains DA availability at...

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Source

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Identifiers

PMID: 22514303
DOI: 10.1523/JNEUROSCI.6033-11.2012
PMCID: PMC3342037

Genes

AMPH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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