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Article

Multicolor Quantum Dot Tracking Uncovers Phenotypic Rescue of DAT A559V Aberrant Diffusion Upon D2R Antagonism.

ACS chemical neuroscience - 18 Feb 2026

Torres Ruben, Kovtun Oleg, McBride James R, Bellocchio Laurel G, Rosenthal Sandra J

Abstract excerpt

The human dopamine transporter (DAT) is a presynaptic transmembrane protein that facilitates the reuptake of synaptically released dopamine. Several lines of evidence indicate that DAT dysfunction is linked to neuropsychiatric disorders. Moreover, the lateral membrane diffusion and clustering propensity of DAT are emergent properties that may factor into functional dopamine signaling. The disorder-associated DAT...

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PMID: 41642719
DOI: 10.1021/acschemneuro.5c00897
PMCID: PMC12921695

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