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Article

Analysis of MTNR1B gene polymorphisms in relationship with IRS2 gene variants, epicardial fat thickness, glucose homeostasis and cognitive performance in the elderly.

Chronobiology international - 1 Jan 2017

Mazzoccoli Gianluigi, Dagostino Mariangela Pia, Paroni Giulia, Seripa Davide, Ciccone Filomena, Addante Filomena, Favuzzi Giovanni, Grandone Elvira, Avola Roberto, Mazza Tommaso, Fusilli Caterina, Greco Antonio, De Cosmo Salvatore

Abstract excerpt

ABSTARCT Genome-wide association studies pinpointed common variants in or near the MTNR1B gene encoding MT2 melatonin receptor to be strongly associated with fasting glucose levels. IRS2 gene polymorphisms impact insulin resistance and epicardial fat (EF) thickness, which in turn is correlated with visceral adiposity, cognitive ability and risk for metabolic plus cardiovascular disease. We aimed to discover the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptor, Melatonin, MT2

Source

Identifiers

PMID: 28708046
DOI: 10.1080/07420528.2017.1340894

Genes

IRS2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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