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Article

Association between MTNR1B polymorphisms and obesity in African American: findings from the Jackson Heart Study.

BMC medical genomics - 21 May 2021

Tchio Cynthia, Musani Solomon K, Quarshie Alexander, Tosini Gianluca

Abstract excerpt

BACKGROUND: Melatonin is a hormone that is secreted at night by the pineal gland. It exerts its function by binding to the MT1 and MT2 receptors, which are encoded by the MTNR1A and MTNR1B genes, respectively. Previous studies reveal that MTNR1B variants are associated with insulin secretion impairments and an increased body mass index (BMI) in individuals of European and Asian ancestries. Obesity is highly...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Body Mass Index

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Share to Polymorphism, Single Nucleotide

Share to Receptor, Melatonin, MT2

Share to Sleep Initiation and Maintenance Disorders

Source

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Identifiers

PMID: 34020621
DOI: 10.1186/s12920-021-00983-2
PMCID: PMC8138980

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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