Article
Na(V)1.1 channels are critical for intercellular communication in the suprachiasmatic nucleus and for normal circadian rhythms.
Proceedings of the National Academy of Sciences of the United States of America - 7 Feb 2012
Han Sung, Yu Frank H, Schwartz Michael D, Linton Jonathan D, Bosma Martha M, Hurley James B, Catterall William A, de la Iglesia Horacio O
Abstract excerpt
Na(V)1.1 is the primary voltage-gated Na(+) channel in several classes of GABAergic interneurons, and its reduced activity leads to reduced excitability and decreased GABAergic tone. Here, we show that Na(V)1.1 channels are expressed in the suprachiasmatic nucleus (SCN) of the hypothalamus. Mice carrying a heterozygous loss of function mutation in the Scn1a gene (Scn1a(+/-)), which encodes the pore-forming...
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