Article
SIK3-HDAC4 in the suprachiasmatic nucleus regulates the timing of arousal at the dark onset and circadian period in mice.
Proceedings of the National Academy of Sciences of the United States of America - 14 Mar 2023
Asano Fuyuki, Kim Staci J, Fujiyama Tomoyuki, Miyoshi Chika, Hotta-Hirashima Noriko, Asama Nodoka, Iwasaki Kanako, Kakizaki Miyo, Mizuno Seiya, Mieda Michihiro, Sugiyama Fumihiro, Takahashi Satoru, Shi Shoi, Hirano Arisa, Funato Hiromasa, Yanagisawa Masashi
Abstract excerpt
Mammals exhibit circadian cycles of sleep and wakefulness under the control of the suprachiasmatic nucleus (SCN), such as the strong arousal phase-locked to the beginning of the dark phase in laboratory mice. Here, we demonstrate that salt-inducible kinase 3 (SIK3) deficiency in gamma-aminobutyric acid (GABA)-ergic neurons or neuromedin S (NMS)-producing neurons delayed the arousal peak phase and lengthened the...
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