Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clinicopathological and molecular characteristics of RSPO fusion-positive colorectal cancer.

British journal of cancer - 1 Oct 2022

Hashimoto Taiki, Takayanagi Daisuke, Yonemaru Junpei, Naka Tomoaki, Nagashima Kengo, Yatabe Yasushi, Shida Dai, Hamamoto Ryuji, Kleeman Sam O, Leedham Simon J, Maughan Timothy, Takashima Atsuo, Shiraishi Kouya, Sekine Shigeki

Abstract excerpt

BACKGROUND: RSPO fusions that lead to WNT pathway activation are potential therapeutic targets in colorectal cancer (CRC), but their clinicopathological significance remains unclear. METHODS: We screened 1019 CRCs for RSPO fusions using multiplex reverse transcription-PCR. The RSPO fusion-positive tumours were subjected to whole-exome sequencing (WES). RESULTS: Our analysis identified 29 CRCs with RSPO fusions...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Colorectal Neoplasms
Share to CTNNB1 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Fusion

Share to NRAS gene

Share to RNF43 gene

Share to Mutation

Share to Thrombospondins

Share to Wnt Signaling Pathway

Source

Open in PubMed Open full text

Identifiers

PMID: 35715628
DOI: 10.1038/s41416-022-01880-w
PMCID: PMC9470590

Genes

APC
BRAF
CTNNB1
EIF3E
KRAS
NRAS
PTPRK
RNF43
RSPO2
RSPO3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clinicopathological and molecular characteristics of RSPO fusion-positive colorectal cancer.PMID 35715628Read ↗

Incidence and clinical significance of 491 known fusion genes in a large cohort of Japanese patients with colorectal cancer.Semantic proximity Read ↗

Comprehensive Analysis of R-Spondin Fusions and RNF43 Mutations Implicate Novel Therapeutic Options in Colorectal Cancer.Semantic proximity Read ↗

Recurrent R-spondin fusions in colon cancer.Semantic proximity Read ↗

Organoid cultures of early-onset colorectal cancers reveal distinct and rare genetic profiles.Semantic proximity Read ↗

R-Spondins 2 and 3 Are Overexpressed in a Subset of Human Colon and Breast CancersSemantic proximity Read ↗

R-Spondin chromosome rearrangements drive Wnt-dependent tumour initiation and maintenance in the intestineSemantic proximity Read ↗

Incidence of RSPO3 rearrangements in advanced colorectal cancer patients detected by NGS and their relationship with disease characteristicsSemantic proximity Read ↗

A Systematic Analysis of Oncogenic Gene Fusions in Primary Colon CancerSemantic proximity Read ↗

The role of R-spondin proteins in cancer biologySemantic proximity Read ↗

Frequent PTPRK-RSPO3 fusions and RNF43 mutations in colorectal traditional serrated adenoma.Semantic proximity Read ↗

Molecular Characterization and Therapeutic Targeting of Colorectal Cancers Harboring Receptor Tyrosine Kinase FusionsSemantic proximity Read ↗

RSPO2 as Wnt signaling enabler: Important roles in cancer development and therapeutic opportunitiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.