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Plasma carboxypeptidase U (CPU, CPB2, TAFIa) generation during in vitro clot lysis and its interplay between coagulation and fibrinolysis.

Thrombosis and haemostasis - 26 Jul 2017

Leenaerts Dorien, Aernouts Jef, Van Der Veken Pieter, Sim Yani, Lambeir Anne-Marie, Hendriks Dirk

Abstract excerpt

Carboxypeptidase U (CPU, CPB2, TAFIa) is a basic carboxypeptidase that is able to attenuate fibrinolysis. The inactive precursor procarboxypeptidase U is converted to its active form by thrombin, the thrombin-thrombomodulin complex or plasmin. The aim of this study was to investigate and characterise the time course of CPU generation in healthy individuals. In plasma of 29 healthy volunteers, CPU generation was...

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Source

Identifiers

PMID: 28692110
DOI: 10.1160/TH17-02-0097

Genes

CPB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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