Article
Patients with cirrhosis have a disbalance between coagulation and fibrinolysis resulting in a prothrombotic phenotype.
Journal of thrombosis and haemostasis : JTH - 1 Jun 2025
Willems Ruth Anne Laura, Zanetto Alberto, Campello Elena, de Simone Ilaria, Bulato Cristiana, Konings Joke, Kramer Matthijs, Tufaha Samia, Russo Francesco Paolo, Senzolo Marco, Burra Patrizia, Cate Hugo Ten, de Vos-Geelen Judith, Roest Mark, Simioni Paolo, de Laat Bas, Huskens Dana
Abstract excerpt
BACKGROUND: Patients with cirrhosis develop multiple hemostatic alterations. Although fibrinolysis is also affected by liver disease, studies have produced conflicting results, highlighting the need for a reliable fibrinolysis assay. Assessing the kinetics of plasmin generation (PG) is a new method to study the fibrinolytic state of cirrhosis patients. OBJECTIVES: This study aimed to compare fibrinolysis between...
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