Article
Procarboxypeptidase U (TAFI) and the Thr325Ile proCPU polymorphism in patients with hereditary mucocutaneous hemorrhages.
Clinica chimica acta; international journal of clinical chemistry - 1 Mar 2009
Matus Valeria, Willemse Johan, Quiroga Teresa, Goycoolea Manuela, Aranda Eduardo, Panes Olga, Pereira Jaime, Hendriks Dirk, Mezzano Diego
Abstract excerpt
BACKGROUND: Patients with hereditary mucocutaneous bleeding are difficult to diagnose and many of them fulfill the category of bleeders of unknown cause (BUC). The pathogenic role of hyperfibrinolysis has received little attention, despite the successful use of antifibrinolytic drugs in treating many of these patients. Theoretically, decreased plasma procarboxypeptidase U (proCPU) levels or lower carboxypeptidase...
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