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Article

The polypeptide tunnel system in the ribosome and its gating in erythromycin resistance mutants of L4 and L22.

Molecular cell - 1 Jul 2001

Gabashvili I S, Gregory S T, Valle M, Grassucci R, Worbs M, Wahl M C, Dahlberg A E, Frank J

Abstract excerpt

Variations in the inner ribosomal landscape determining the topology of nascent protein transport have been studied by three-dimensional cryo-electron microscopy of erythromycin-resistant Escherichia coli 70S ribosomes. Significant differences in the mouth of the 50S subunit tunnel system visualized in the present study support a simple steric-hindrance explanation for the action of the drug. Examination of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11511371
DOI: 10.1016/s1097-2765(01)00293-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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